Lewis C Cantley Selected Research

phosphatidylinositol 5-phosphate

3/2020	Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
1/2020	Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
1/2016	Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
11/2013	Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
6/2004	Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.

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Lewis C Cantley Research Topics

Disease

151	Neoplasms (Cancer) 04/2022 - 07/2002
22	Breast Neoplasms (Breast Cancer) 01/2022 - 12/2005
14	Carcinogenesis 01/2020 - 03/2008
12	Lung Neoplasms (Lung Cancer) 01/2022 - 08/2005
12	Insulin Resistance 12/2019 - 01/2002
11	Neoplasm Metastasis (Metastasis) 11/2021 - 07/2010
8	Obesity 12/2021 - 03/2007
7	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 04/2013
7	Prostatic Neoplasms (Prostate Cancer) 10/2020 - 09/2008
6	Tuberous Sclerosis (Bourneville's Disease) 02/2022 - 07/2002
6	Adenocarcinoma 01/2022 - 04/2013
6	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 08/2010
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 03/2005
5	Carcinoma (Carcinomatosis) 04/2022 - 10/2006
5	Triple Negative Breast Neoplasms 01/2022 - 01/2016
5	Type 2 Diabetes Mellitus (MODY) 12/2019 - 06/2004
4	Endometrial Neoplasms (Endometrial Cancer) 04/2022 - 07/2011
4	Brain Neoplasms (Brain Tumor) 01/2021 - 12/2009
4	Body Weight (Weight, Body) 01/2018 - 06/2004
4	Melanoma (Melanoma, Malignant) 01/2017 - 12/2011
3	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 09/2010
3	Bites and Stings (Sting) 01/2021 - 01/2018
3	COVID-19 01/2021 - 05/2020
3	Nausea 01/2019 - 04/2014
3	Hypersensitivity (Allergy) 08/2013 - 03/2005
3	Crohn Disease (Crohn's Disease) 07/2012 - 12/2004
3	Inborn Genetic Diseases (Disease, Hereditary) 09/2005 - 10/2002
2	Weight Gain 12/2021 - 03/2007
2	Leukemia 01/2021 - 01/2016
2	Virus Diseases (Viral Diseases) 12/2020 - 03/2002
2	Infections 12/2020 - 05/2020

Drug/Important Bio-Agent (IBA)

30	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2002
21	Phosphotransferases (Kinase)IBA 12/2020 - 03/2004
21	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2020 - 01/2002
20	Insulin (Novolin)FDA Link 12/2021 - 01/2002
18	Proteins (Proteins, Gene)FDA Link 03/2021 - 10/2002
17	Pharmaceutical PreparationsIBA 01/2022 - 03/2007
14	Pyruvate KinaseIBA 01/2022 - 03/2008
14	EnzymesIBA 01/2021 - 06/2004
14	Protein Isoforms (Isoforms)IBA 01/2019 - 03/2008
12	Serine (L-Serine)FDA Link 01/2020 - 05/2009
10	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2022 - 07/2002
9	Glutamine (L-Glutamine)FDA Link 01/2016 - 08/2010
8	ErbB Receptors (EGF Receptor)IBA 12/2015 - 03/2005
7	TOR Serine-Threonine KinasesIBA 09/2010 - 10/2002
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2012
6	FructoseIBA 03/2021 - 01/2013
6	LipidsIBA 01/2021 - 05/2009
6	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 03/2002
6	NucleotidesIBA 01/2017 - 09/2007
5	Tuberous Sclerosis Complex 2 ProteinIBA 02/2022 - 07/2002
5	Hormones (Hormone)IBA 01/2022 - 11/2005
5	AlpelisibIBA 01/2022 - 01/2017
5	Biological ProductsIBA 12/2021 - 07/2004
5	Fatty Acids (Saturated Fatty Acids)IBA 11/2021 - 01/2013
5	NVP-BKM120IBA 11/2020 - 11/2012
5	CytokinesIBA 05/2020 - 12/2004
5	phosphatidylinositol 5-phosphateIBA 03/2020 - 06/2004
5	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 01/2020 - 07/2011
5	Small Interfering RNA (siRNA)IBA 01/2020 - 03/2008
5	Amino Acids FDA Link 01/2020 - 05/2009
5	Metformin (Glucophage)FDA LinkGeneric 12/2019 - 12/2005
5	Mechanistic Target of Rapamycin Complex 1IBA 09/2015 - 09/2008
4	MK 2206IBA 04/2022 - 01/2019
4	Tuberous Sclerosis Complex 1 ProteinIBA 02/2022 - 10/2002
4	Oxaloacetic Acid (Oxalacetic Acid)IBA 12/2020 - 01/2018
4	Glutamic Acid (Glutamate)FDA Link 12/2020 - 01/2018
4	Transaminases (Aminotransferases)IBA 12/2020 - 01/2018
4	CarbonIBA 01/2020 - 07/2011
4	SugarsIBA 01/2019 - 01/2012
4	trans-sodium crocetinate (crocetin)IBA 09/2015 - 10/2002
4	IsoenzymesIBA 06/2013 - 02/2010
4	Gefitinib (Iressa)FDA Link 05/2007 - 03/2005
4	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 05/2007 - 01/2002
3	olaparibIBA 01/2022 - 11/2012
3	CarbohydratesIBA 12/2021 - 10/2015
3	ChemokinesIBA 01/2021 - 05/2007
3	VaccinesIBA 12/2020 - 08/2004
3	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2020 - 07/2011
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 07/2004
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 12/2008
3	Transcription Factors (Transcription Factor)IBA 10/2019 - 03/2002
3	Letrozole (Femara)FDA LinkGeneric 01/2019 - 04/2014
3	Oxygen (Dioxygen)IBA 01/2019 - 11/2009
3	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2019 - 12/2015
3	Everolimus FDA Link 07/2017 - 09/2008
3	MTOR InhibitorsIBA 03/2017 - 07/2004
3	Drug CombinationsIBA 01/2017 - 07/2011
3	Tyrosine Kinase InhibitorsIBA 01/2017 - 08/2005
3	LeptinIBA 12/2016 - 05/2008
3	Messenger RNA (mRNA)IBA 12/2015 - 02/2010
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 08/2013 - 03/2004
3	Lactic Acid (Lactate)FDA LinkGeneric 07/2011 - 11/2009
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2009 - 08/2005
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2007 - 08/2005
2	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 02/2022 - 08/2003
2	ChromatinIBA 01/2021 - 10/2019
2	Proline (L-Proline)FDA Link 10/2020 - 05/2015

Therapy/Procedure

55	Therapeutics 04/2022 - 03/2004
3	Radiotherapy 04/2022 - 01/2020